MOCS2

Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]

真核生物的钼酶采用一种独特的钼辅因子（MoCo），该辅因子由一种蝶啶衍生物，即钼蝶啶，以及具有催化活性的金属钼组成。MoCo通过异二聚酶钼蝶啶合成酶从前体Z合成。钼蝶啶合成酶的大亚基和小亚基均由该基因通过重叠的开放阅读框编码。最初认为这些蛋白是由一个双顺反子转录本编码的。现在则认为它们是由单顺反子转录本编码的。此外，该位点还发现了可进行选择性剪接的转录本，这些转录本编码大亚基和小亚基。[提供者：RefSeq，2008年7月]