Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor.

Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor. Descriptor: 1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one, CHLORIDE ION, Proto-oncogene tyrosine-protein kinase receptor Ret Authors: Lee, C.C, Spraggon, G. Deposit date: 2021-08-17 Release date: 2022-01-19 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.51 Å) Cite: Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- d ]pyrimidine RET Inhibitors. Acs Med.Chem.Lett., 12, 2021

磷酸化RET酪氨酸激酶结构域与吡咯并[2,3-d]嘧啶类抑制剂结合的晶体结构。描述符：1-(4-{(1s,3s)-3-[4-氨基-5-(3-氨基-4-氯苯基)-7H-吡咯并[2,3-d]嘧啶-7-基]环丁基}哌嗪-1-基)乙-1-酮、氯离子、原癌基因酪氨酸蛋白激酶受体Ret。作者：Lee, C.C.、Spraggon, G.。沉积日期：2021-08-17。发布日期：2022-01-19。末次修改日期：2024-11-06。检测方法：X射线衍射（分辨率3.51 Å）。引用文献：《新型吡咯并[2,3-d]嘧啶类RET抑制剂的脱靶选择性与耐受性》，《ACS药物化学通讯》，2021年，第12卷。