Data for: The peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates of different morphology

The peculiarities of an anticancer drug 5-fluorourocil adsorption by aluminosilicate matrices of different morphology — BEA zeolites, layered silicates with saponite (Mg3Si4O10(OH)2.H2O) and montmorillonite (Na0.2Al1.8Mg0.2Si4O10(OH)2.H2O) structures, nanotubular halloysite (Al2Si2O5(OH)4.2H2O) were investigated. The influence of the polarity of the solvent used (water, acetone, ethanol), the pH-environment (pH=5, 8, 11), the morphology (framed, layered and nanotubular) and chemical composition (Al2O3 content 0-40 wt.%) of the initial matrix on the amount of the adsorbed drug was studied. In order to prevent errors associated with the possibility of the existence of various tautomeric forms of fluorouracil in solutions, studies of the adsorption processes were carried out exclusively using thermal analysis coupled with mass spectrometry. It has been established that the efficiency of 5-fluorourocyl adsorption and the loading conditions are largely determined by the chemical composition of the initial aluminosilicate matrix and its morphology. The highest adsorption capacity for fluorouracil in any conditions of saturation is characteristic for zeolite, and the smallest - for halloysite matrix.本研究探究了不同形貌硅铝酸盐基质（aluminosilicate matrices）对抗癌药物5-氟尿嘧啶（5-fluorouracil）的吸附特性，所涉基质包括BEA沸石（BEA zeolite）、具有皂石（saponite，Mg₃Si₄O₁₀(OH)₂·H₂O）与蒙脱石（montmorillonite，Na₀.₂Al₁.₈Mg₀.₂Si₄O₁₀(OH)₂·H₂O）结构的层状硅酸盐，以及纳米管状埃洛石（nanotubular halloysite，Al₂Si₂O₅(OH)₄·2H₂O）。 本研究同时考察了溶剂极性（涵盖水、丙酮、乙醇）、环境pH值（pH=5、8、11）、初始基质的形貌（骨架状、层状与纳米管状）以及化学组成（氧化铝（Al₂O₃）含量0~40 wt.%）对药物吸附量的影响。 为规避因溶液中氟尿嘧啶存在多种互变异构体而引发的实验误差，本研究仅采用热分析-质谱联用法（thermal analysis coupled with mass spectrometry）开展吸附过程相关测试。 研究证实，5-氟尿嘧啶的吸附效率与负载条件在很大程度上由初始硅铝酸盐基质的化学组成及其形貌所决定。在任意饱和条件下，BEA沸石均表现出最高的氟尿嘧啶吸附容量，而埃洛石基质的吸附容量最低。