Increased cough sensitivity in Ttll1−/− mice.

Wild-type (WT) and Ttll1−/− mice were nebulized with saline and capsaicin (10 and 50 μM). A graph displaying the increased number of coughs (post-treatment–pretreatment). Even low doses (10 μM) of capsaicin increased the number of coughs in the Ttll1−/− mice but not in the WT mice. High doses (50 μM) of capsaicin increased the number of coughs in the WT and Ttll1−/− mice. (n = 5 mice per group; mean ± SEM; *P Ttll1−/− mice; †P