Transcriptional profiling of 6 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 conditional knockout mice [Msh2_6mon]. Transcriptional profiling of 6 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 conditional knockout mice [Msh2_6mon]

As part of collaboration between UCLA and CHDI, UCLA is creating knockouts (KOs) of 123 genes, implicated in Huntington's disease (HD) through various computational modeling efforts. Striatum and cortex were isolated from 6-month-old Msh2 flox/flox mice crossed with the Rgs9Cre+/- and Q140 knock-in (KI) HD mice and their respective controls. Transcriptomic analysis (RNASeq) was performed on 4 genotypes: Het (Q140) KI X Rgs9Cre+/-, Het (Q140) KI X Rgs9Cre+/- X Msh2fl/fl, Het (Q140) KI, and WT, 8 replicates per genotype. Overall design: RNASeq analysis was performed on samples from the striatum and cortex tissues of 6-month-old Het (Q140) KI X Rgs9Cre+/-, Het (Q140) KI X Rgs9Cre+/- X Msh2fl/fl, Het (Q140) KI, and WT mice. N = 8 per group (4F/4M). UPDATE: [Mar-22-2026] The genotypes of the Samples were updated.