PYCARD recruits procaspase-1 via CARD

Procaspase-1 is recruited via a CARD-CARD interaction with ASC. This creates procaspase-1 clustering which is believed to stimulate procaspase-1 autocleavage, generating the p10/p20 fragments that assemble into the active capsase-1 tetramer (Schroder & Tschopp, 2010).

Procaspase-1通过CARD-CARD相互作用被ASC募集，进而形成procaspase-1的簇集。这种簇集被认为能够激发procaspase-1的自身切割，从而生成p10/p20片段，这些片段最终组装成具有活性的caspase-1四聚体（Schroder & Tschopp, 2010）。