Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 3,4-bis(4-hydroxyphenyl)thiophene 1,1-dioxide

Protein Data Bank Japan2024-03-06 更新2026-03-21 收录

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Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 3,4-bis(4-hydroxyphenyl)thiophene 1,1-dioxide Descriptor: 3,4-bis(4-hydroxyphenyl)-2,5-dihydro-1H-1lambda~6~-thiophene-1,1-dione, 3-methyl-6-phenyl-3H-imidazo[4,5-b]pyridin-2-amine, Estrogen receptor, ... Authors: Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. Deposit date: 2016-10-12 Release date: 2017-01-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.103 Å) Cite: Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017

雌激素受体α（ER-alpha）配体结合域（Y537S突变体）与3,4-双(4-羟基苯基)噻吩1,1-二氧化物形成复合物的晶体结构描述项：3,4-双(4-羟基苯基)-2,5-二氢-1H-1λ⁶-噻吩-1,1-二酮、3-甲基-6-苯基-3H-咪唑并[4,5-b]吡啶-2-胺、雌激素受体（Estrogen receptor）等作者：Nwachukwu J.C.、Erumbi R.、Srinivasan S.、Bruno N.E.、Nowak J.、Izard T.、Kojetin D.J.、Elemento O.、Katzenellenbogen J.A.、Nettles K.W. 提交日期：2016-10-12 发布日期：2017-01-18 最后修改日期：2024-03-06 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.103 Å 引用文献：《系统结构生物学分析配体对ERα的影响可预测细胞对环境雌激素与抗激素治疗的响应》，发表于Cell Chem Biol，2017年，第24卷

创建时间：

2016-10-12