five

LFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 1).

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https://www.omicsdi.org/dataset/pride/PXD037232
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To assess the impact of the bactericidal compounds CymA and ecumicin on the mycobacterial proteome and to monitor proteome remodeling by the AAA+ ClpC1 protease machinery, we performed a LFQ proteomics analysis treating the cells at sub-bactericidal compound concentration. We identified new players of the mycobacterial ClpC1 stress response (ClpC2 and ClpC3), as novel bacterial antibiotic resistance mechanism.
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2023-06-07
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