Spatiotemporal transcriptomic changes of human ovarian aging and the key regulatory role of FOXP1

The understanding of how aging affects the cellular and molecular components of the human ovary and contributes to age-related fertility decline is still limited. Here, we systematically characterize human ovarian aging by combining single-cell RNA sequencing. We provide a comprehensive understanding of human ovarian aging and a resource for the development of new diagnostic biomarkers and therapeutic strategies.