Comparative genomics of ESBL-producing Escherichia coli ST131 isolates

Recent rapid increase in ESBL-producing Enterobacteriaceae isolate is closely related to the emergence and worldwide spread of Escherichia coli ST131 clone. Of the ST131 clone, CTX-M-15-producing H30Rx subclone has been identified as the responsible subclone of this pandemic. In this study, we investigated clinical ESBL-producing E. coli ST131 isolates in Japan using whole genome sequencing and comaparative genomic analysis to define responsible subclones spread in Japan.