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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Homo sapiens

NIAID Data Ecosystem2026-03-09 收录

碱基编辑

基因编辑效率

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA316460 数据链接链接失效反馈

官方服务：

资源简介：

Characterization of in vitro and cellular efficiencies of BE1, BE2, and BE3

应用场景：

创建时间：

2016-03-25

碱基编辑

基因治疗

Programmable base editing of RNA enables rewriting the genetic codes on specific sites. Current tools for specific RNA editing dependent on the assembly or recruitment of the guide RNA into an RNA/pro

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Additional file 2 of Increased prime edit rates in KCNQ2 and SCN1A via single nicking all-in-one plasmids

基因编辑效率

癫痫相关基因

Additional file 2: Table S1. Individual data values of all data represented in this manuscript.

Figshare2023-07-14 更新30

Test the editing efficiency of AsCas12a and SpCas9 in different settings

基因编辑效率

CRISPR-Cas系统

We compared AsCas12a-mediated LAHR with traditional SpCas9-mediated HDR in two endogenous genes: ALK and CACNA1D. Besides, we also explored if the location of the nucleotide substitution could influen

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Homo sapiens and zebrafish Targeted Locus (Loci)

CRISPR-Cpf1

基因编辑效率

We find that pre-crRNAs comprising a full-length direct repeat (full-DR-crRNA) sequence with specific stem-loop G-C base substitutions exhibit increased editing efficiencies compared with the standard

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Raw number results for cloning efficiency of BRP, CAT and CSFVRP, and recombinant expression for the individual BRP and CAT genes.

基因编辑效率

重组蛋白表达

Raw number results for cloning efficiency of BRP, CAT and CSFVRP, and recombinant expression for the individual BRP and CAT genes.

NIAID Data Ecosystem30