A Highly Enantioselective Homoenolate Michael Addition/Esterification Sequence of Cyclohexadienone-Tethered Enals via NHC Catalysis
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https://figshare.com/articles/dataset/A_Highly_Enantioselective_Homoenolate_Michael_Addition_Esterification_Sequence_of_Cyclohexadienone-Tethered_Enals_via_NHC_Catalysis/21932019
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资源简介：
Reported here is a highly enantioselective homoenolate
Michael
addition/esterification sequence of cyclohexadienone-tethered enals
via N-heterocyclic carbene (NHC) catalysis, affording the enantiopure cis-hydrobenzofurans, cis-hydroindoles,
and cis-hydroindenes. The NHC catalyst bearing a
nitro group greatly enhances the stereocontrol, and a bulky N-aryl substituent of the triazolium salt in the catalyst
is helpful for inhibiting the further aldol condensation after homoenolate
Michael addition. The utility of this protocol is highlighted by a
gram-scale experiment and versatile downstream transformations.
创建时间：
2023-01-20
