Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA615045
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资源简介：
In our study, mutant zebrafish lines of autophagy-related genes beclin1 were generated by CRISPR/Cas9 gene-editing technology.Interestingly, male beclin1 heterozygous zebrafish displayed liver defects in the morphology and histology, including abnormal hepatocyte proliferation, hemorrhagic and inflammatory phenotypes. In order to better study the phenotype of beclin1 heterozygous zebrafish, we extracted RNA from the liver of 12-month-old male beclin1 heterozygotes and WT for transcriptomics research.
创建时间：
2020-03-25
