Circulating cell-free DNA dataset extracted from metastatic castration-resistant prostate cancer patients across two races, African American men and Caucasian men

This study is a cross-sectional, comparative cohort analysis of plasma-derived cell-free DNA (cfDNA) from men with metastatic castration-resistant prostate cancer (mCRPC), designed to identify ancestry-associated differences in cfDNA variant landscapes between African American men (AAM) and Caucasian men (CM). The final curated dataset included 88 plasma samples (66 CM, 22 AAM) after exclusion of one sample for inadequate sequencing quality and two samples lacking racial information.