Commercial Glyphosate Formulations Exceed Active Ingredient Toxicity via Mitochondrial ROS and Transcriptomic Disruption

This dataset contains RNA sequencing (RNAseq) tables derived from HepG2 human liver carcinoma cells exposed to glyphosate (GLY) or a glyphosate-based herbicide (GBH). The research aimed to investigate whether the GBH formulation exerts greater cellular toxicity than GLY alone. The dataset includes normalized gene expression values and differential expression analysis comparing control, GLY-treated, and GBH-treated samples. These data can be used to explore transcriptional changes, identify affected pathways, and further investigate mechanisms of GBH-induced toxicity. Overall, the RNAseq results indicate that GBH exposure leads to broader transcriptional alterations than GLY, involving genes related to oxidative stress, endoplasmic reticulum (ER) stress, autophagy, and apoptosis. The dataset provides a valuable resource for researchers studying the molecular responses to glyphosate-based herbicides.