Synthesis of Bi‑, Ter‑, and Quaterpyridinecarboxylates via Propargylisoxazole–Pyridine Rearrangement
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A flexible method was developed for the synthesis of 2,2′-bi-, 2,2′:6′,2″-ter-, and 2,2′:6′,2′′:6′′,2‴-quaterpyridines containing a nicotinic acid moiety. The approach involves the Fe(II)/Au(I)-catalyzed rearrangement of key 4-propargylisoxazole building blocks bearing a pyrid-2-yl or quinolin-2-yl substituent at the 3-position and Pd(0)-catalyzed cross-coupling reactions.
创建时间:
2020-04-08



