Data for Radial arm maze tests and Novel object recognition test

Background Aging population is rapidly expanding worldwide, and
age-related cognitive impairments proves detrimental for achieving a
better productive and quality of life. Lack of effective therapies for
age-related cognitive impairment focuses attention on developing
preventive strategies, such as nutritional interventions, cell therapies
and environmental manipulations. The objective of present study was to
explore the comparative benefits of potential memory-enhancing strategies
like supplementation of choline and docosahexaenoic acid (DHA) or
administration of conditioned media derived from human embryonic kidney
stem cells (HEK-CM) or exposure to environmental enrichment (EE), that
attenuates cognitive impairments in aging mice. Results Spatial memory and
cognition were decreased in normal aging mice. Aged mice exposed to
dietary Ch-DHA or HEK-CM showed significant enhancement in spatial
learning tasks, memory and cognition compared to the same in age-matched
NAC mice. Ch-DHA and HEK-CM treated mice committed significantly lesser
reference memory errors and attained a higher percentage of correct
choices in spatial learning and memory tasks. Moreover, on testing for
cognition in NORT, significantly higher number of visits to the novel
object was observed in Ch-DHA supplemented and HEK-CM administered aging
mice whereas HEK-CM and EE mice groups showed significantly greater number
of visits to familiar object, when compared to same in age-matched NAC and
HI-HEKCM groups respectively. Conclusion Supplementation of Ch-DHA and HEK
CM treatment strategies have a higher potential [~ 20-30%] for enhancing
spatial learning, memory and cognition in normal aged mice, whereas
exposure to enriched environment seems to enhance only their short term
memory.