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CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

ChEBI2014-10-07 更新2026-07-21 收录

发育疾病机制

自闭症谱系障碍分子遗传学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-61492 数据链接链接失效反馈

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资源简介：

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

应用场景：

创建时间：

2014-10-07

斑马鱼遗传

发育疾病机制

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Effect of DRP1 mutations on synaptic development during iPSC-derived cortical neuron maturation

发育疾病机制

iPSC神经元模型

With the advent of exome sequencing, a growing number of children are being identified with de novo loss of function mutations in the large GTPase essential for mitochondrial fission - Dynamin Related

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Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

唐氏综合征基因表达

发育疾病机制

Many features of Down syndrome might result from the overdosage of only a few genes located in a critical region of chromosome 21. To search for these genes, cosmids mapping in this region were isolat

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Transcriptome analysis of Chd8 S62X heterozygote mutant and wild-type mice

发育疾病机制

大鼠转录组学

Autism spectrum disorders (ASD) are ~4-times more common in males than females, and CHD8 (a chromatin remodeler)-related ASD shows a strong male bias (~5:1), although the underlying mechanism remains

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Single cell transcriptomic analysis of mutant MECP2 human neural cells over a time-course of in vitro differentiation

单细胞转录组学

发育疾病机制

Single cell transcriptomic analysis of mutant MECP2 human neural cells over a time-course of in vitro differentiation

ChEBI2024-11-17 更新20