The effects of inhibitors of EGF, VEGF and FGF signaling pathways on compound 10-induced angiogenesis in VRI-treated zebrafish.

The semi-quantitative analysis of effects of inhibitors on angiogenesis activity of 10 in VRI-treated zebrafish: ○, inactive, 80%; +++, 60–80%; ++, 40–60%; +, 20%–40% as compared to the 10 post-treated zebrafish embryos. aZebrafish embryos treated with the indicated concentration of inhibitor had been showed toxicity and the inhibitory effect was not determined.