Developmental programs in neuroblastoma [RNA-seq SK-N-BE(2)C ATRA]. Developmental programs in neuroblastoma [RNA-seq SK-N-BE(2)C ATRA]

Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. We investigate developmental origins of neuroblastoma, the role of oncogenic MYCN in blocking normal differentiation and evaluate therapeutic interventions to overcome differentiation blocks. Here, we provide expression profiles of SK-N-BE(2)C cells upon treatment with ATRA or solvent control. Overall design: RNA-seq in cell line SK-N-BE(2)C after treatment with 10 µM ATRA or solvent control (ethanol) for 144 hours