Complexes of N- and O‑Donor Ligands as Potential Urease Inhibitors
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https://figshare.com/articles/dataset/Complexes_of_N-_and_O_Donor_Ligands_as_Potential_Urease_Inhibitors/12156861
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资源简介：
We
report five new transition-metal complexes that inhibit the
urease enzyme. Barbituric acid (BTA), thiobarbituric
acid (TBA), isoniazid (INZ), and nicotinamide
(NCA) ligands were employed in complexation reactions.
The resulting complexes were characterized using a variety of analytical
techniques including infra-red and UV–vis spectroscopy, 1H NMR spectroscopy, elemental analysis, and single-crystal
X-ray diffraction analysis. We describe two mononuclear complexes
with a general formula {[M(NCA)2(H2O)4](BTA)2(H2O)}, where
M = Co (1) and Zn (2), a mononuclear complex
{[Ni(NCA)2(H2O)4](TBA)2(H2O)} (3), and two
polymeric chains of a general formula {[M(INZ) (H2O)3](BTA)2(H2O)3}, where M = Co (4) and Zn (5). These complexes displayed significant urease enzyme inhibition
with IC50 values in the range of 3.9–19.9 μM.
创建时间：
2020-04-20
