Data for: Differential inflammatory potential of particulate matter (PM) size fractions from Imperial Valley, CA

Ultrafine, fine, and coarse PM samples were collected and extracted separately. Analyses of the chemical compositions for each size fraction were performed, and biological response was measured by exposing a cell line of macrophages to particles and quantifying subsequent gene expression. Biological measurements demonstrated coarse PM induced an inflammatory response in macrophages measured in increases of inflammatory markers IL-1ß, IL-6, IL-8 and CXCL2 expression, whereas ultrafine and fine PM only demonstrated significant increases in expression of CYP1a1. These differential responses were due not only to particle size, but to the distinct chemical profiles of each size faction as well.本研究分别采集并提取了超细颗粒物（ultrafine PM）、细颗粒物（fine PM）与粗颗粒物（coarse PM）样本。针对各粒径组分的化学成分开展分析，并通过将巨噬细胞系暴露于颗粒物环境、定量检测后续基因表达水平的方式，完成生物学响应的测定。生物学检测结果显示，粗颗粒物可诱导巨噬细胞产生炎症反应，具体表现为炎症标志物IL-1β、IL-6、IL-8及CXCL2的表达水平显著上调；而超细颗粒物与细颗粒物仅能使CYP1a1的表达出现显著上调。上述差异响应不仅与颗粒物粒径相关，同时也与各粒径组分独特的化学特征密切相关。