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TRAP-seq of mouse astrocytes involved in central nervous system remyelination
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2025-07-08
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PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination. PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination
The function of poly(ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination of the central nervous system (CNS) remains enigmatic. Here we report that PARP1 is an intrinsic driver for olig
NIAID Data Ecosystem60
MOESM12 of Development of a central nervous system axonal myelination assay for high throughput screening
Additional file 12: Table S1. NCC library screen data set.
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Mutations in Brg1 can cause Coffin-Siris syndrome, where a patient had white matter defects and partial agenesis of the corpus callosum; however, Brg1 functions in CNS myelination and remyelination is
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Genome-wide maps of Wnt effector Tcf7l2/Tcf4 occupancy in oligodendrocyte during CNS myelination. Rattus norvegicus
We performed genome-wide profiling of Tcf7l2 occupancy during oligodendrocyte differentiation and identified the key enzymes involved in cholesterol metabolism and essential for CNS myelination. Overa
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The lncRNA genomic landscape of oligodendrocytes reveals myelination control by a lncOL1/Suz12 complex in the CNS [RNASeq_lncOL1]
Long noncoding RNAs (lncRNAs) are emerging as important regulators of cellular functions, but their roles in myelination in the CNS remain undefined. Through de novo transcriptome reconstruction at mu
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