Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid)

Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid) Descriptor: DI(HYDROXYETHYL)ETHER, Hypoxanthine-guanine phosphoribosyltransferase, {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid) Authors: Teran, D, Guddat, L.W. Deposit date: 2017-08-17 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.795 Å) Cite: Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Negl Trop Dis, 12, 2018

布氏锥虫（Trypanosoma brucei）次黄嘌呤-鸟嘌呤磷酸核糖转移酶（Hypoxanthine guanine phosphoribosyltransferase）与{[(2S)-3-(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)丙烷-1,2-二基]双(氧乙烷-2,1-二基)}双(膦酸)形成的复合物。配体描述符：二(羟乙基)醚（DI(HYDROXYETHYL)ETHER）、次黄嘌呤-鸟嘌呤磷酸核糖转移酶、{[(2S)-3-(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)丙烷-1,2-二基]双(氧乙烷-2,1-二基)}双(膦酸)；作者：Teran D、Guddat L.W.；沉积日期：2017-08-17；发布日期：2018-03-14；最后修改日期：2023-10-04；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.795埃（Å）；引用文献：《布氏锥虫6-氧代嘌呤补救途径作为药物发现潜在靶点的评估》，《PLoS被忽视热带病》（PLoS Negl Trop Dis），2018年，第12卷。