Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction

We
report the first example of a silyl-Negishi reaction between
secondary zinc organometallics and silicon electrophiles. This palladium-catalyzed
process provides direct access to alkyl silanes. The delicate balance
of steric and electronic parameters of the employed DrewPhos ligand
is paramount to suppressing isomerization and promoting efficient
and selective cross-coupling.