Distinct Effects of Semaglutide and Tirzepatide on Metabolic and Inflammatory Gene Expression in Brown Adipose Tissue of Mice Fed a High-Fat, High-Fructose Diet

This investigation compared the transcriptomic responses of semaglutide (GLP-1 receptor agonist) and tirzepatide (dual GIP/GLP-1 receptor agonist) on BAT in mice fed a high-fat, high-fructose diet (HFHFD). These outcomes enhance our understanding of the metabolic actions of GLP-1 and dual GIP/GLP-1 receptor agonists, providing a conceptual basis for future BAT-targeted therapeutic strategies.