Gene expression screening during early granulation tissue formation (I). Rattus norvegicus

Hydroxyapatite-coated cellulose induces a quicker and stronger inflammatory response compared to uncoated cellulose. Furthermore, the coated cellulose increases the homing at circulating bone-marrow derived progenitor cells. For this reason, Illumina microarray was used to study the early gene expression of the forming granulation tissue in the hydroxyapatite-coated sponges. Overall design: A total of six samples from six different rats was analyzed. Three samples were collected after 24 hours of implantation and three after 72 hours of implantation.