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we evaluated the the prognosis impact of monocyte percentage at diagnosis in newly diagnosed DLBCL patients. This retrospective cohort study firstly displayed a significant association between elevated monocyte percentage and a poor survival outcome. The data of monocytes percentage, achieved from CBC, may be widely used and easily incorporated into clinical practice. In addition, monocyte percentage presented prognostic information independent of NCCN-IPI and is also able to provide additional prognostic information when combined with NCCN-IPI.