Supporting data and analysis code for TCN1 and HMMR in atopic dermatitis

Analysis inputs, code and results supporting the prioritisation of TCN1 and HMMR as hub genes in atopic dermatitis: bulk transcriptomics, Mendelian randomization, machine learning and SHAP interpretation, pathway enrichment, immune deconvolution, single-cell analyses and virtual knockout, paired lesional/non-lesional spatial transcriptomics, drug prediction and docking, and 100 ns apo and TCN1-GW843682X molecular dynamics trajectories with MM/GBSA endpoint energetics. The release contains 8 main and 17 supplementary figures (25 figures in total), numerical source tables and SHA256 provenance records. See README and REPRODUCIBILITY for contents and reconstruction instructions. Data are distributed under CC BY 4.0; analysis code files are additionally available under the MIT license.