Crystal structure of the GluK2 ligand-binding domain in complex with L-glutamate and BPAM344 at 1.60 A resolution

Crystal structure of the GluK2 ligand-binding domain in complex with L-glutamate and BPAM344 at 1.60 A resolution Descriptor: 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, GLUTAMIC ACID, ... Authors: Bay, Y, Jeppesen, M.E, Frydenvang, K, Kastrup, J.S. Deposit date: 2023-11-08 Release date: 2024-09-18 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2. Febs Lett., 598, 2024分辨率为1.60埃的GluK2配体结合域与L-谷氨酸及BPAM344复合物的晶体结构 描述项：4-环丙基-7-氟-3,4-二氢-2H-1,2,4-苯并噻二嗪1,1-二氧化物、氯离子、谷氨酸等 作者：Bay Y、Jeppesen M.E.、Frydenvang K.、Kastrup J.S. 提交日期：2023-11-08 发布日期：2024-09-18 最后修改日期：2024-11-06 实验方法：X射线衍射（1.6埃） 引用文献：正变构调节剂BPAM344与L-谷氨酸可诱导GluK2配体结合域形成活性样构象。《FEBS快报》，598卷，2024年