Processed directed evolution data

CSV tables. Rows are full-length genotypes from PacBio sequencing (Cry1ac) or 600-nt paired end Illumina sequencing (TadA). Columns are samples or timepoints. Values are frequencies such that columns sum to 1.<br>Following Badran et al.'s methods, Cry1ac genotypes were filtered to those with &gt;1% frequency at any timepoint, which roughly corresponded to filtering all genotypes with fewer than 5 reads in every timepoint (see our Online Methods for more info.)<br>The same filter was applied on TadA data at a 0% frequency cutoff (equivalent to no filtering) due to higher read depth and accuracy from Illumina sequencing. A threshold of 5% was used to determine common mutations. Frequencies were combined for PANCEs but kept separate for each of three PACEs (see Online Methods).