Microarray profiling of rats treated for 21 days with haloperidol (0.25 mg/kg/d), risperidone (5 mg/kg/d) or vehicle

SD rats were dosed with gold standard antipsychotic therapies, haloperidol or risperidone, at doses aimed at achieving therapeutically relevant drug exposures. Tissues were collected after 21 days of delivery to examine the impact of this treatment on gene expression in frontal cortex, hippocampus and striatum.本研究以SD大鼠为受试对象，给予标准抗精神病治疗方案，即氟哌啶醇（haloperidol）或利培酮（risperidone），给药剂量旨在达到治疗相关的药物暴露水平。于给药21天后采集组织样本，以考察该治疗对前额叶皮层（frontal cortex）、海马体（hippocampus）及纹状体（striatum）基因表达的影响。