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CRISPR screens uncover CRTC3 as a regulator of IFN-γ induced ferroptosis in hepato-cellular carcinoma

NIAID Data Ecosystem2026-05-02 收录

CRISPRi筛选

肝细胞癌铁死亡

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE206907 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-06-24

相关数据集

raw data for main figures.xlsx

CRISPRi筛选

功能基因组学

data used to create main figures for: Park et. al., Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA, BMC Biol, 2023.

Figshare2023-01-28 更新70

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

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Genes of CRISPR-Cas9 negative screening.

CRISPRi筛选

肿瘤免疫逃逸

We compared changes in sgRNA abundance between T24 cells challenged and unchallenged by CD8+ T cells, and then performed negative screening (p < 0.01, log2Fold change < −1.0, and good sgRNAs ≥ 5). (X

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Genetic vulnerability of knockout cancer lines

癌症基因组数据

CRISPRi筛选

Genome-wide CRISPR/Cas9 library screen was performed in isogenic cell lines. Three biological replicates were used. Cells were harvested at initiation of screen and at specific time points following c

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Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.

干细胞鉴定

CRISPRi筛选

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms,

NIAID Data Ecosystem20