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Programmed minichromosome elimination. Tetrahymena thermophila

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NIAID Data Ecosystem2026-03-09 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA326452
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Tetrahymena thermophila displays nuclear dualism and contains a somatic nucleus (macronucleus, MAC) and a germline nucleus (micronucleus, MIC) in the same cell. During conjugation, the MIC goes through mitosis, meiosis, and cross-fertilization to generate zygotic nuclei, which further divide and develop into new MAC and MIC. The developing new MAC undergoes a dramatic series of programmed DNA rearrangements, including the elimination of ~34 % of the genome (from 157 Mb to 104 Mb) and the fragmentation of the 5 MIC chromosomes into about 225 minichromosomes that are retained in the MAC.
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2016-06-21
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