Crystal structure of human Haspin (GSG2) kinase bound to MU2181

Protein Data Bank Japan2025-09-24 更新2026-04-19 收录

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Crystal structure of human Haspin (GSG2) kinase bound to MU2181 Descriptor: NICKEL (II) ION, Serine/threonine-protein kinase haspin, ~{N}-(1,4-dimethylpyrazol-3-yl)-3-(1,2-thiazol-5-yl)thieno[3,2-b]pyridin-5-amine Authors: Kraemer, A, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2024-06-05 Release date: 2024-09-11 Last modified: 2025-09-24 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode. Angew.Chem.Int.Ed.Engl., 64, 2025

人源Haspin（GSG2）激酶与MU2181结合的晶体结构描述：镍(II)离子、丝氨酸/苏氨酸蛋白激酶Haspin、~N-(1,4-二甲基吡唑-3-基)-3-(1,2-噻唑-5-基)噻吩并[3,2-b]吡啶-5-胺作者：Kraemer A、Paruch K、Knapp S、结构基因组学联盟（Structural Genomics Consortium, SGC）提交日期：2024-06-05 发布日期：2024-09-11 最后修改日期：2025-09-24 实验方法：X射线衍射（X-RAY DIFFRACTION，2.9 Å）引用文献：《噻吩并[3,2-b]吡啶：针对结合模式可变的未充分研究蛋白激酶的高选择性抑制剂的极具吸引力的骨架》，Angew.Chem.Int.Ed.Engl., 64, 2025

创建时间：

2024-06-05