Integrated analysis of DNA methylation and gene expression profiles identified S100A9 as a potential biomarker in ulcerative colitis

In this research, 90 differential expression mRNAs (DEMs), 72 differential expression lncRNAs (DELs) and biological functions and pathway were identified in ulcerative colitisby (UC) integrated analysis. Potential therapeutic target for treatment was preliminary verified by qRT-PCR experiment and bioinformatics analysis. Differential expression mRNAs (DEMs) and lncRNAs (DELs) in UC samples compared with healthy samples were identified, meanwhile, differential methylation promoters (DMPs) in UC samples compared with healthy controls were obtained. Besides, functional enrichment analyses, and construction of functional regulatory and interaction network were conducted. Finally, DEMs and DELs was verified by qRT-PCR experiment and potential therapeutic targets for the development of novel treatments was preliminary identified.