Higher Interleukin 13 differentiates patients with a positive history of suicide attempts in major depressive disorder

Every 40 seconds one person dies from suicide worldwide, half of which are related to depression. Neuroinflammation has been reported in neuropsychiatricconditions, including major depressive disorder (MDD). Preliminary findings suggested a link between inflammation and suicidal behavior. Nevertheless,to the best of our knowledge, no previous study explored how a wide range of cytokines may differentiate lifetime suicidal behaviors (i.e. positive history of suicide attempts) in patients affected by MDD. In 28 healthy controls (HC), 28 MDD patients with a positive history of attempting suicide (SA), and 28 MDD patients with a negative history (nSA), we determined concentrations of immune analytes using an ultra-sensitive Pro Human Cytokine Group 27-Plex Panel and Chemokine immunoassay panels (Bioplex). To deal with the 27 highly correlated cytokines we applied two different statistical approaches that reduce the dimensionality of data: Principal Component Analysis, exploring if suicidality may be related to a comprehensive derived inflammatory state, and elastic-net penalized regression that allows considering as predictor every single cytokine. Biological data are not uploaded due to ethical restrictions. https://doi.org/10.1016/j.jadr.2021.100254全球范围内，每40秒便有一人死于自杀，其中近半数与抑郁症相关。神经炎症已被报道存在于包括重性抑郁症（Major Depressive Disorder, MDD）在内的各类神经精神疾病中。已有初步研究结果显示炎症与自杀行为存在关联。然而，据我们所知，此前尚无研究探讨多种细胞因子能否区分重性抑郁症患者的终生自杀行为（即存在自杀企图阳性史）。 本研究纳入28名健康对照者（healthy controls, HC）、28名存在自杀企图阳性史的重性抑郁症患者（suicide attempt, SA）以及28名无自杀企图史的重性抑郁症患者（nSA），采用超灵敏的人细胞因子27-Plex组试剂盒及趋化因子免疫测定试剂盒（Bioplex）对免疫分析物的浓度进行检测。 针对27个高度相关的细胞因子，我们采用两种不同的数据降维统计方法：其一为主成分分析（Principal Component Analysis），用于探究自杀行为是否与综合推导的炎症状态相关；其二为弹性网络惩罚回归，该方法可将单个细胞因子全部作为预测变量纳入分析。 由于伦理限制，本研究未上传相关生物学数据。 https://doi.org/10.1016/j.jadr.2021.100254