Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 1-aminoisoquinoline and PKI (5-24)

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 1-aminoisoquinoline and PKI (5-24) Descriptor: ISOQUINOLIN-1-AMINE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha Authors: Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. Deposit date: 2020-11-10 Release date: 2021-11-24 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published

与1-氨基异喹啉（ISOQUINOLIN-1-AMINE）以及PKI（5-24）共结晶的环腺苷单磷酸依赖型蛋白激酶A（cAMP-dependent protein kinase A）的晶体结构。描述项：1-氨基异喹啉（ISOQUINOLIN-1-AMINE）、环腺苷单磷酸依赖型蛋白激酶催化亚基α（cAMP-dependent protein kinase catalytic subunit alpha）、环腺苷单磷酸依赖型蛋白激酶抑制剂α（cAMP-dependent protein kinase inhibitor alpha）。作者：Oebbeke, M、Wienen-Schmidt, B、Heine, A、Klebe, G。提交日期：2020-11-10；发布日期：2021-11-24；末次修改日期：2024-11-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.69埃（Å）。引用文献：基于片段的药物设计——片段的微小化学变化可引发结合特性的显著变化，待发表（Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published）