Data from 3 compounds prioritized after titration assays. Compound descriptors and screening data in agonist and antagonist modes in HEK cells, and HEK cells expressing Sm.TRPMPZQ are shown. (XLSX)
omega-Aga-IIIA, an 8.5-kDa peptide toxin isolated from the venom of Agelenopsis aperta, was found to be a highly potent inhibitor of Ca channels in cardiac muscle and in peripheral and central neurons
L-type Ca2+ channel (VGCC) mediated Ca2+ influx in vascular smooth muscle cells (VSMC) contributes to the functional properties of large arteries in arterial stiffening and central blood pressure regu
