PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with starting material

PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with starting material Descriptor: 3,4-dichlorobenzoate, PH-interacting protein Authors: Grosjean, H, Aimon, A, Hassel-Hart , S, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Biggin, P.C, Spencer, J, von Delft, F. Deposit date: 2021-01-22 Release date: 2021-02-17 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography. Angew.Chem.Int.Ed.Engl., 64, 2025

PanDDA分析课题组存档数据集——PH相互作用蛋白（PH-interacting protein, PHIP）与起始物料3,4-二氯苯甲酸（3,4-dichlorobenzoate）复合物的晶体结构。作者：Grosjean, H、Aimon, A、Hassel-Hart, S、Krojer, T、Talon, R、Douangamath, A、Koekemoer, L、Biggin, P.C、Spencer, J、von Delft, F。存档日期：2021-01-22；发布日期：2021-02-17；最后修改日期：2026-02-18。实验方法：X射线衍射（X-RAY DIFFRACTION，1.15 Å）。引用文献：《结合多步阵列合成与高通量晶体学的活性位点纯化筛选法（Binding-Site Purification of Actives, B-SPA）可实现片段命中化合物的高效规模化开发》，《德国应用化学国际版（Angew.Chem.Int.Ed.Engl.）》，第64卷，2025年。