Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form)

Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form) Descriptor: (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') Authors: Kondo, J, Koganei, M, Maianti, J.P, Ly, V.L, Hanessian, S. Deposit date: 2012-08-22 Release date: 2013-04-03 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites Chemmedchem, 8, 2013

本数据集为原生动物细胞质核糖体解码位点与6'-羟基异西索米星（6'-hydroxysisomicin）结合的晶体结构（P21212晶型）。结构描述式：(1S,2S,3R,4S,6R)-4,6-二氨基-3-{[(2S,3R)-3-氨基-6-(羟甲基)-3,4-二氢-2H-吡喃-2-基]氧基}-2-羟基环己基 3-脱氧-4-C-甲基-3-(甲氨基)-β-L-阿拉伯吡喃糖苷，对应的RNA序列为(5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3')。作者为Kondo J、Koganei M、Maianti J.P、Ly V.L、Hanessian S。数据提交日期：2012-08-22，发布日期：2013-04-03，最后修改日期：2024-03-20。实验方法为X射线衍射（分辨率3 Å）。引用信息：《结合于细菌与原生动物核糖体解码位点的生物活性6'-羟基异西索米星晶体结构》，刊载于《Chemmedchem》2013年第8卷。