Adam24
收藏rgd.mcw.edu2025-03-26 收录
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This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Male mice lacking the encoded protein exhibit reduced fertility due to the higher incidence of polyspermic embryos. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
本基因编码一种属于ADAM（溶解酶和金属蛋白酶）家族的内肽酶成员，该家族在多种生物过程中扮演着重要角色，包括细胞信号传导、粘附和迁移。该基因在精子发生过程中以调控方式表达。编码的前体蛋白经过蛋白水解处理，生成成熟的、具有功能的金属蛋白酶酶类。缺乏编码蛋白的雄性小鼠因多精子胚胎发生率较高而表现出生育能力降低。该基因位于第8号染色体上邻近其他ADAM基因。[由RefSeq提供，2016年5月]
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