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Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteins [RNA-seq]

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE173183
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The purpose of this study was to determine the transcriptional regulatory similarities and differences in the FET/ETS translocations that have been identified as drivers of Ewing sarcoma. Endogenous EWS/FLI was knocked-down in the Ewing sarcoma A673 cell line and FET/ETS cDNA constructs were expressed in these cells via viral transduction. Cells were collected after 8 days and total RNA was extracted to study the transcriptomic profiles of each FET/ETS fusion protein. 2 biological replicates of each sample were performed for this experiment. Please note that each processed data was generated from both replicates and is linked to the corresponding *R1 sample records
创建时间:
2021-09-18
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