Enantioselective and Regioselective Copper-Catalyzed Borocyanation of 1‑Aryl-1,3-Butadienes

A multicomponent
copper-catalyzed enantio- and regioselective borocyanation
of 1-aryl-1,3-butadienes has been developed. The method provides access
to functionalized allylic nitriles in up to 90% yield and 94% ee and thus overcomes some of the long-standing problems
associated with the enantioselective insertion of cyano groups into
unsaturated organic molecules. Both boron and cyano functionalities
can be used as handles for selective manipulation.