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Haploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [γH2AX localization]

ChEBI2014-06-19 更新2026-07-21 收录

癌症复制应激机制

DNA损伤定位分析

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-51558 数据链接链接失效反馈

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资源简介：

Haploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [γH2AX localization]

应用场景：

创建时间：

2014-06-19

癌症复制应激机制

PPM1D靶向干预

Oncogene-induced replication stress has been recognized as a major cause of genome instability in cancer cells. Increased expression of cyclin E1 caused by amplification of the CCNE1 gene is a common

NIAID Data Ecosystem20

Protein arginine methyltransferase 5 mediates the increase in interferon stimulated genes during replication stress. Protein arginine methyltransferase 5 mediates the increase in interferon stimulated genes during replication stress

癌症复制应激机制

PRMT5功能基因组学

Replication stress (RS) is a hallmark of cancer and is defined as the perturbation of DNA replication that results in stalled or collapsed DNA replication forks. Chemotherapeutic drugs exploit this ph

NIAID Data Ecosystem20

Senataxin (SETX) prevents Myc-induced replicative stress [DRIP-seq]

癌症复制应激机制

RNA-DNA杂交体

Here we investigated the RNA helicase Senataxin (SETX), an enzyme that resolve RNA-DNA hybrids and R-loops, to address its role in preventing replicative stress by oncogenic Myc. Silencing of SETX led

NIAID Data Ecosystem00

NR4A1 suppresses cancer replication stress through R-loop-dependent inhibition of immediate early gene transcriptional elongation [PRO-seq]

癌症复制应激机制

转录调控

Deregulation of oncogenic proliferative signals triggers replication stress in cancer cells to which they must adapt. Immediate early genes (IEGs), identified by their rapid stress-induced transient b

NIAID Data Ecosystem20

Senataxin (SETX) prevents Myc-induced replicative stress [DRIP-seq]. Senataxin (SETX) prevents Myc-induced replicative stress [DRIP-seq]

癌症复制应激机制

RNA-DNA杂交体

NIAID Data Ecosystem10