Validation of CNNLOH estimates using FISH.

CNNLOH estimates just outside of the chromosome 13q14 region in two CLL samples based on analysis of SNP data compared with CNNLOH estimates obtained from FISH analysis on chromosome 13q14 in Gunnarsson et al 2008. Due to too few regions with deletions in these samples SNP data could not be used to quantify the fraction of normal cells. Instead flow cytometry data from Gunnarsson et al 2008 was used to obtain the fraction of normal cells. This information together with the SNP array data was used to quantify CNNLOH.