The prediction performance of different approaches that incorporate information on tissue of origin in LASSO.

The second column shows which subset of the training samples were used for training. The third column shows how tissue information was used. The fourth column shows the number of drugs for which a statistically significant discrimination between resistant and sensitive patients was obtained (one-sided Mann Whitney U test). The fifth column shows the total number of drugs included in the evaluation, and the sixth column shows the combined p-value (using Fisher’s method) for all the drugs in the analysis.