Structure-based network scores for SARS-CoV-2 CD8+ T cell epitopes

Supplemental Figure 3 for article titled "Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses." File includes a list of SARS-CoV-2 epitopes tested by HLA class I-peptide stability assay with highlighted sequences of highly networked, HLA stabilizing epitopes mutated in variants B.1.1.7 (red), B.1.351 (green), P.1 (orange), B.1.617 (purple). Each row indicates a highly networked SARS-CoV-2 epitope and columns include the following: HLA, Peptide #, Epitope Code, Epitope Sequence, Gene, Amino Acid, Protein, Protein Region, Network Score, NetMHC Binding Score, HLA Stabilization Score, 50% Experimental Binder (T/F). Please contact Anusha Nathan at [e-mail] with questions.本材料为论文《针对SARS-CoV-2变异株和沙贝病毒属（Sarbecovirus）的结构指导式T细胞疫苗设计》的补充图3。该文件包含了经人类白细胞抗原（HLA）I类-肽稳定性实验检测的SARS-CoV-2表位列表，其中高亮标注了在B.1.1.7（红色）、B.1.351（绿色）、P.1（橙色）、B.1.617（紫色）变异株中发生突变的高连通性、可稳定HLA结合的表位序列。每一行对应一个高连通性SARS-CoV-2表位，各列信息如下：HLA、肽编号（Peptide #）、表位编码（Epitope Code）、表位序列（Epitope Sequence）、基因（Gene）、氨基酸（Amino Acid）、蛋白质（Protein）、蛋白质区域（Protein Region）、连通性得分（Network Score）、NetMHC结合得分、HLA稳定化得分、50%实验结合阳性结果（T/F）。如有疑问，请联系Anusha Nathan，邮箱地址为[e-mail]。