Expression data of metformin treated wild type and parietal cell- specific AMPK-deficient mice

Genes related to AMPK activation, cellular respiration, and metabolism are enriched in the gastric parietal cell population. Metformin is known activator of AMPK. We used microarray analysis to identify metformin targets in mature parietal cells and in parietal cell progenitors. RNA from gastric corpus was isolated from wild type BL6 mice that were treated with or without metformin for 14 days to determine mature parietal cell metformin targets. Mice with parietal cell-specific loss of AMPK have significantly decreased parietal cell number and impaired parietal cell maturation. Gastric epithleium from these mutant mice treated with or without metformin was compared to determine metformin targets in parietal cell progenitor and non-parietal cells.