Vitamin A deficiency results in an uncontrolled immune response and aggravates liver damage during obstructive cholestasis

Conclusions: We conclude that vitamin A deficiency dramatically aggravates liver damage caused by obstructive cholestasis. The transcriptome analysis suggests that a disturbed immune response may be the predominant causative factor.结论：本研究证实维生素A缺乏可显著加重梗阻性胆汁淤积所致的肝损伤。转录组分析结果显示，免疫应答紊乱可能是该过程的主要致病因素。